Search results for "Patient-reported outcomes"

showing 10 items of 19 documents

Health-Related Quality of Life Issues Experienced by Thoracic and Breast Sarcoma Patients: A Rare and Understudied Group

2021

Thoracic and breast sarcomas constitute a rare subgroup within the sarcoma population. There is limited knowledge about their health-related quality of life (HRQoL) and a valid disease-specific HRQoL instrument is lacking. This qualitative study aimed to investigate the HRQoL issues experienced by a small group of thoracic and breast sarcoma patients. Semi-structured interviews with 19 thoracic and four breast sarcoma patients were conducted and thematically analysed. Physical issues mentioned by both groups were fatigue, sleep disturbances, pain, wound infections, and symptoms related to chemotherapy and radiotherapy. Tightness in the back and restrictions in performing tasks above arm hei…

medicine.medical_specialtychest sarcomaBreast SarcomaPopulationbreast sarcomaSocial issuesArticleRC0254Tumours of the digestive tract Radboud Institute for Health Sciences [Radboudumc 14]All institutes and research themes of the Radboud University Medical CenterSDG 3 - Good Health and Well-beingQuality of lifemedicinethoracic sarcomaSocial determinants of healtheducationeducation.field_of_studybusiness.industryRGeneral Medicinemedicine.diseaseMental healthhealth-related quality of lifeMoodpatient-reported outcomesPhysical therapyMedicineSarcomabusinessRare cancers Radboud Institute for Health Sciences [Radboudumc 9]Journal of Clinical Medicine
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Burden of disease in patients with Morquio A syndrome: results from an international patient-reported outcomes survey

2013

WOS: 000335253700001

AdultQuality of lifemedicine.medical_specialtyActivities of daily livingInternationalityAdolescentDiseaseShort staturechemistry.chemical_compoundWheelchairQuality of lifeElosulfase alfaMedicineHumansGenetics(clinical)Pharmacology (medical)ChildGenetics (clinical)FatigueMobilityMedicine(all)Pain measurementPatient-reported outcomesbusiness.industryData CollectionResearchMucopolysaccharidosis IVGeneral MedicineGaithumanitiesEQ-5D-5LchemistryWheelchairsJoint painPhysical therapymedicine.symptombusinessMorquio A syndromeOrphanet Journal of Rare Diseases
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Exploring the Relationship between Disease Awareness and Outcomes in Patients with Chronic Obstructive Pulmonary Disease

2020

<b><i>Background:</i></b> Disease awareness is a challenge in the management of chronic obstructive pulmonary disease (COPD). <b><i>Objectives:</i></b> The aim of this analysis was to explore the association between COPD optimal and suboptimal awareness, clinical parameters, and the following patient-reported outcomes: modified Medical Research Council (mMRC), Treatment Satisfaction Questionnaire (TSQM-9), COPD Assessment Test (CAT), Morisky Medication-Taking Adherence Scale (MMAS-4), and Brief Illness Perception Questionnaire (B-IPQ). <b><i>Methods:</i></b> This post hoc analysis of the SAT study included all enrolled …

Pulmonary and Respiratory MedicineMaleHealth Knowledge Attitudes Practicemedicine.medical_specialtyChronic ObstructiveHealth BehaviorClinical InvestigationsPulmonary diseaseSocio-culturaleDiseaseSettore MED/10 - Malattie Dell'Apparato RespiratorioSeverity of Illness Indexchronic obstructive pulmonary diseaseTreatment satisfactionIllness perceptionsPulmonary DiseasePulmonary Disease Chronic ObstructiveDiagnostic Self EvaluationInternal medicineSurveys and QuestionnairesPost-hoc analysismedicineSettore MED/10HumansAdherence awareness chronic obstructive pulmonary disease patient-reported outcomesIn patientawarenessPatient Reported Outcome MeasuresAgedCOPDPracticebusiness.industryHealth KnowledgeSelf-Managementmedicine.diseaseSymptom Flare UpAdherence; Awareness; Chronic obstructive pulmonary disease; Patient-reported outcomes; Aged; Female; Health Knowledge Attitudes Practice; Humans; Italy; Male; Patient Reported Outcome Measures; Patient Satisfaction; Severity of Illness Index; Surveys and Questionnaires; Symptom Flare Up; Diagnostic Self Evaluation; Health Behavior; Pulmonary Disease Chronic Obstructive; Self-Management; Treatment Adherence and ComplianceTreatment Adherence and ComplianceItalyPatient SatisfactionAdherencepatient-reported outcomesAttitudesCopd assessment testFemalebusiness
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Update on the ESCEO recommendation for the conduct of clinical trials for drugs aiming at the treatment of sarcopenia in older adults

2020

Abstract Background In 2016, an expert working group was convened under the auspices of the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis (ESCEO) and formulated consensus recommendations for the conduct of clinical trials for drugs to prevent or treat sarcopenia. Aims The objective of the current paper is to provide a 2020 update of the previous recommendations in accordance with the evidence that has become available since our original recommendations. Methods This paper is based on literature reviews performed by members of the ESCEO working group and followed up with face to face meetings organized for the whole group to make amendments and discuss…

AgingSarcopeniaGeriatrics & GerontologyStandardizationDiseaseReviewRecommendationsFace-to-face0302 clinical medicineQUALITY-OF-LIFEGAIT SPEEDClinical trial; Drug registration; Guidelines; Recommendations; Sarcopenia; Treatment; Aged; Humans; Muscle Strength; Osteoarthritis; Osteoporosis; Pharmaceutical Preparations; Sarcopenia030212 general & internal medicineMUSCLE MASSDIETARY-PROTEINClinical trialPhysical limitationsPharmaceutical Preparations/dk/atira/pure/sustainabledevelopmentgoals/good_health_and_well_beingPatient-reported outcomeGRIP STRENGTHLife Sciences & Biomedicinemedicine.medical_specialtyNUTRITIONAL-STATUSBODY-COMPOSITION030209 endocrinology & metabolismGuidelines03 medical and health sciencesClinical trial · Sarcopenia · Guidelines · Recommendations · Drug registration · TreatmentSDG 3 - Good Health and Well-beingOsteoarthritismedicineHumansMuscle StrengthDrug registrationAgedScience & Technologybusiness.industryWORKING GROUPmedicine.diseaseComorbidityClinical trialTreatmentSarcopeniaPATIENT-REPORTED OUTCOMESPhysical therapyOsteoporosisGeriatrics and GerontologyPHYSICAL PERFORMANCEbusinessAging Clinical and Experimental Research
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Real-world evidence from a European cohort study of patients with treatment resistant depression : Baseline patient characteristics

2021

Journal of affective disorders 283, 115-122 (2021). doi:10.1016/j.jad.2020.11.124

AdultMaleDisease burden; Health-related quality of life; Major depressive disorder; Observational study; Patient-reported outcomes; Socio-economic status; Adult; Cohort Studies; Europe; Female; Humans; Male; Middle Aged; Quality of Life; Depressive Disorder Major; Depressive Disorder Treatment-Resistantmedicine.medical_specialtyHealth-related quality of lifeSocio-economic statusMajor depressive disorderCohort Studies03 medical and health sciencesDepressive Disorder Treatment-Resistant0302 clinical medicineQuality of lifeObservational studyInternal medicinemedicineHumansMedical historyDepression (differential diagnoses)Disease burdenDepressive DisorderDepressive Disorder MajorPatient-reported outcomesDisease burden Health-related quality of life Major depressive disorder Observational study Patient-reported outcomes Socio-economic statusbusiness.industryTreatment-ResistantMajorDisease burdenMiddle Agedmedicine.disease030227 psychiatry3. Good healthEuropePsychiatry and Mental healthClinical PsychologyPresenteeismQuality of LifeMajor depressive disorderFemalebusinessTreatment-resistant depression030217 neurology & neurosurgeryCohort study
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Bloating is associated with worse quality of life, treatment satisfaction, and treatment responsiveness among patients with constipation-predominant …

2016

Background The management of bloating is unclear and its relationship with patients' well-being and treatment satisfaction independent of other abdominal symptoms is uncharacterized. We evaluated the association of bloating with patient-reported outcomes. Methods Thirty-nine centers for functional gastrointestinal disorders joined the laxative inadequate relief survey. We enrolled 2203 consecutive outpatients with functional constipation (FC) or constipation-predominant irritable bowel syndrome (IBS-C) in two cross-sectional waves. Both wave 1 and 2 included the SF-12, the patient assessment of constipation-symptoms (PAC-SYM), and the treatment satisfaction questionnaire for medication (TSQ…

AdultMaleQuality of lifemedicine.medical_specialtyConstipationCross-sectional studyPhysiologyBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Physiology; Endocrine and Autonomic Systems; GastroenterologyBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Adult; Constipation; Cross-Sectional Studies; Female; Flatulence; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Prevalence; Quality of Life; Surveys and QuestionnairesEndocrine and Autonomic System03 medical and health sciences0302 clinical medicineBloatingQuality of lifeSurveys and QuestionnairesInternal medicinePrevalencemedicineFlatulenceHumansIrritable bowel syndromePatient-reported outcomeChronic constipationSettore MED/12 - GastroenterologiaPatient-reported outcomesTreatment satisfactionBloating; Chronic constipation; Functional constipation; Irritable bowel syndrome; Patient-reported outcomes; Quality of life; Treatment satisfaction; Adult; Constipation; Cross-Sectional Studies; Female; Flatulence; Humans; Irritable Bowel Syndrome; Male; Middle Aged; Prevalence; Quality of Life; Surveys and Questionnaires; Physiology; Endocrine and Autonomic Systems; GastroenterologyEndocrine and Autonomic Systemsbusiness.industryChronic constipationBloatingSettore MED/09 - MEDICINA INTERNAGastroenterologyMiddle Agedmedicine.diseaseIrritable bowel syndromeSettore MED/18 - Chirurgia GeneraleCross-Sectional StudiesTolerability030220 oncology & carcinogenesisPhysical therapyFunctional constipationFemale030211 gastroenterology & hepatologymedicine.symptombusinessConstipationFunctional constipation
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Effects of a structured educational intervention in moderate-to-severe elderly asthmatic subjects.

2019

Background: Adherence to inhaled drugs is linked to patients’ satisfaction with their device, and an incorrect use can negatively affect the outcomes of asthma treatment. We speculated that this is particularly true in elderly asthmatic subjects. Aim: We performed a national pre-post interventional multicentre study, enrolling moderate-to-severe asthmatic subjects aged ≥65 ​years treated with fixed inhaled combination drugs by dry powder inhaler (DPI) or pressurized metered dose inhaler (pMDI). Adherence and critical errors were evaluated by means of validated questionnaires at first visit (V1) and after 3–6 months (V2). At V1, subjects underwent intensive training on the correct use of the…

Vital capacityACT asthma control testExacerbationSAE severe asthma exacerbationSF12chlorofluorocarbonsmental health composite scoreEDUCA elderly and device use in chronic asthmaPCS physical health composite scoreACT asthma control test; AHDS hospital anxiety depression scale; Asthma; CFC chlorofluorocarbons; Device misuse; EDUCA elderly and device use in chronic asthma; Education; Elderly; FEV1 forced expiratory volume 1s second; FVC forced vital capacity; ICS inhaled corticosteroids; LABA long-acting β2 agonist; LAMA long-acting muscarinic antagonists; MCS mental health composite score; PCS physical health composite score; PROs patient-reported outcomes; SAE severe asthma exacerbation; SF12 short form health survey; mMRC modified medical research councilEDUCAFEV10302 clinical medicineElderlyImmunology and AllergyMedicine030223 otorhinolaryngologybiologymMRC modified medical research councilsevere asthma exacerbationmodified medical research councilLAMASAELamaelderly and device use in chronic asthmaMetered-dose inhalerDry-powder inhalerDevice misusePROs patient-reported outcomesCFCPCSpatient-reported outcomesmMRClcsh:Immunologic diseases. AllergyPulmonary and Respiratory Medicinelong-acting β2 agonistmedicine.medical_specialtyImmunologyLABAphysical health composite scoreArticleLAMA long-acting muscarinic antagonistsAHDSEducation03 medical and health sciencesFEV1/FVC ratiolong-acting muscarinic antagonistsforced vital capacitySF12 short form health surveyAsthma; Device misuse; Education; ElderlyInternal medicineMCS mental health composite scoreforced expiratory volume 1s secondAsthmabusiness.industryFEV1 forced expiratory volume 1s secondInhalerasthma control testbiology.organism_classificationmedicine.diseaseCFC chlorofluorocarbonsACTICS inhaled corticosteroidsFVCAsthmaMCShospital anxiety depression scale030228 respiratory systemICSAHDS hospital anxiety depression scaleFVC forced vital capacityPROsshort form health surveyinhaled corticosteroidslcsh:RC581-607businessLABA long-acting β2 agonistThe World Allergy Organization journal
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Disability in moderate chronic obstructive pulmonary disease: Prevalence, burden and assessment-results from a real-life study

2014

<b><i>Background:</i></b> The role of disability and its association with patient-reported outcomes in the nonsevere forms of chronic obstructive pulmonary disease (COPD) has never been explored. <b><i>Objectives:</i></b> The aim of this study was to assess, in a cross-sectional real-life study, the prevalence and degree of disability in moderate COPD patients and to assess its association with health status, illness perception, risk of death and well-being. <b><i>Methods:</i></b> Moderate COPD outpatients attending scheduled visits were involved in a quantitative research program using a questionnaire-based data collec…

MalePulmonary and Respiratory Medicinemedicine.medical_specialtyChronic ObstructiveActivities of daily livingCross-sectional studyHealth StatusPulmonary diseaseChronic obstructive pulmonary disease; Disability; Patient-reported outcomes; Activities of Daily Living; Aged; Cross-Sectional Studies; Disability Evaluation; Female; Health Status; Humans; Italy; Male; Middle Aged; Pulmonary Disease Chronic Obstructive; Pulmonary and Respiratory MedicineSettore MED/10 - Malattie Dell'Apparato RespiratorioChronic obstructive pulmonary disease; Disability; Patient-reported outcomes; Activities of Daily Living; Aged; Cross-Sectional Studies; Disability Evaluation; Female; Health Status; Humans; Italy; Male; Middle Aged; Pulmonary Disease Chronic Obstructive; Pulmonary and Respiratory Medicine; Medicine (all)Illness perceptionsPulmonary DiseasePulmonary Disease Chronic ObstructiveDisability EvaluationActivities of Daily LivingMedicineHumansDisease burdenAgedCOPDDisabilityPatient-reported outcomesbusiness.industryMedicine (all)Chronic obstructive pulmonary diseaseMiddle Agedmedicine.diseaseCross-Sectional StudiesItalyPhysical therapyFemaleRisk of deathbusinessLife study
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Unravelling the heterogeneity of soft tissue and bone sarcoma patients’ health-related quality of life: a systematic literature review with focus on …

2020

Contains fulltext : 229532.pdf (Publisher’s version ) (Open Access) Patients with sarcoma experience many physical and psychological symptoms, adversely affecting their health-related quality of life (HRQoL). HRQoL assessment is challenging due to the diversity of the disease. This review aims to unravel the heterogeneity of HRQoL of patients with sarcoma with regard to tumour location and to summarise the used measures in research. English-language literature from four databases published between January 2000 and April 2019 was reviewed. Studies that described adult sarcoma HRQoL outcomes were included and classified according to primary sarcoma location. Eighty-seven articles met the incl…

AdultCancer Researchmedicine.medical_specialtyConstitutional symptomsPopulationbone sarcomaSoft Tissue NeoplasmsReviewBone Sarcomalcsh:RC254-282Quality of lifeInternal medicineSurveys and QuestionnairesMedicineHumans1506educationeducation.field_of_studyOsteosarcomabusiness.industrySoft tissue sarcomaSarcomamedicine.diseaselcsh:Neoplasms. Tumors. Oncology. Including cancer and carcinogenshumanitieshealth-related quality of lifeSystematic reviewOncologypatient-reported outcomessoft tissue sarcomaQuality of LifeSarcomabusinessPsychosocialRare cancers Radboud Institute for Health Sciences [Radboudumc 9]ESMO Open
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Impact of reslizumab on outcomes of severe asthmatic patients: current perspectives.

2018

Approximately 5%-10% of asthmatics suffer from severe asthma. New biological treatments represent a great opportunity to reduce asthma burden and to improve asthma patients' lives. Reslizumab will soon be available in several European countries. This anti-IL-5 IgG4/kappa monoclonal antibody, administered intravenously at a dose of 3 mg/kg over 20-50 minutes every 4 weeks, has been shown to be safe and effective in patients with 400 eosinophils/mu L or more in their peripheral blood. The clinical effects in reducing asthma exacerbations and in improving the quality of life and lung function are clear, but further research is needed to determine the best biological compound for a specific clu…

Drugmedicine.medical_specialtymedia_common.quotation_subjectReview030204 cardiovascular system & hematologySettore MED/10 - Malattie Dell'Apparato Respiratoriopatient-reported outcomeasthma; patient-reported outcomes; personalized medicine; reslizumabPathogenesis030207 dermatology & venereal diseases03 medical and health sciences0302 clinical medicineReslizumabInternal medicinemedicineAsthmatic patientPathologicalAsthmamedia_commonbusiness.industrypersonalized medicineasthmamedicine.diseasereslizumabpatient-reported outcomesPersonalized medicinebusinessMepolizumabmedicine.drugPatient related outcome measures
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